Description

Description

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5 Meo is a naturally occurring compound that can cause a strong psychedelic state is DMT. Recently it has been proposed that DMT analogues could be used for the treatment of mood disorders. Due to the strong correlation between altered neurogenesis and mood disorders, we tested whether 5-Meo-DMT is able to increase the DG cell proliferation. We show that a single intra-Cerebro-ventricular (ICV) injection of 5-Meo-DMT, the number of bromo deoxyuridine (BrdU+) cells in adult mice DG increases. Furthermore, we found, using a transgenic animal, the Tamoxifen-dependent Cre Recombinase under Doublecortin promoter expressed, that 5 Meo DMT-treated mice, a higher number of newborn DG granule cells (GC) were. We have also shown that these DG-GC after 5-MeO-DMT have a more complex dendritic morphology. Finally a newborn GC was treated with 5-Meo-DMT. in comparison to shorter nachhyperpolarisation potential (AHP) and a higher action potential threshold (AP). Our results show that this DMT affects neurogenesis, and this effect may contribute to the well-known anti-depressive properties of DMT-derived Compounds.

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5-MeO-DMT is a chemical research psychedelic from the Tryptamine class, four to six times stronger than its better-known Cousin  DMT (N,N-Dimethyltryptamine). It comes in a wide variety of trees and shrubs, often together DMT and Bufotenin (5-HO-DMT), as well as in a Toad. 5-MeO DMT can also be produced synthetically.

The Vaporizing or Smoking of 5-MeO-DMT powder is the most common method of administration is. The effect is usually within the first 30 seconds after the consumption of felt, reached its peak after 1 to 15 minutes and lasts for up to half an hour. When taking synthetic 5-MeO-DMT is a threshold dose is about 1-2 mg, while a moderate to strong dose is 5-10 mg. In the case of natural recovery, the threshold dose is 5-10 mg, and a moderate to strong dose of 20-40 mg.

If swallowed, the doses are generally higher, but also, in General, unreliable results. Other, less common routes of Administration are the sublingual administration (under the tongue) and the injection.

The effect of 5-MeO-DMT is strong and is often associated with a loss of physical coordination and control. User experience bright colors, moving environments, or recursive pattern, and possibly even "Umweltorbismus" at higher doses. The visual effects are, however, limited. In contrast to DMT, 5-MeO-DMT is not for its visionary properties. The experience is often described as a "change of perspective", which is characterized by physical, emotional, and conceptual impact.